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Alzheimer's disease

The meaning of «alzheimer's disease»

Alzheimer's disease (AD) is a neurodegenerative disease that usually starts slowly and progressively worsens.[2] It is the cause of 60–70% of cases of dementia.[2][12] The most common early symptom is difficulty in remembering recent events.[1][13] As the disease advances, symptoms can include problems with language, disorientation (including easily getting lost), mood swings, loss of motivation, self-neglect, and behavioral issues.[1][2] As a person's condition declines, they often withdraw from family and society.[1] Gradually, bodily functions are lost, ultimately leading to death.[14] Although the speed of progression can vary, the typical life expectancy following diagnosis is three to nine years.[9][15]

The cause of Alzheimer's disease is poorly understood.[1] There are many environmental and genetic risk factors associated with its development. The strongest genetic risk factor is from an allele of APOE.[16][17] Other risk factors include a history of head injury, clinical depression, and high blood pressure.[1] The disease process is largely associated with amyloid plaques, neurofibrillary tangles, and loss of neuronal connections in the brain.[14] A probable diagnosis is based on the history of the illness and cognitive testing with medical imaging and blood tests to rule out other possible causes.[6] Initial symptoms are often mistaken for normal aging.[1] Examination of brain tissue is needed for a definite diagnosis, but this can only take place after death.[14] Good nutrition, physical activity, and engaging socially are known to be of benefit generally in aging, and these may help in reducing the risk of cognitive decline and Alzheimer's; in 2019 clinical trials were underway to look at these possibilities.[14] There are no medications or supplements that have been shown to decrease risk.[18]

No treatments stop or reverse its progression, though some may temporarily improve symptoms.[2] Affected people increasingly rely on others for assistance, often placing a burden on the caregiver.[19] The pressures can include social, psychological, physical, and economic elements.[19] Exercise programs may be beneficial with respect to activities of daily living and can potentially improve outcomes.[20] Behavioral problems or psychosis due to dementia are often treated with antipsychotics, but this is not usually recommended, as there is little benefit and an increased risk of early death.[21][22]

As of 2020, there were approximately 50 million people worldwide with Alzheimer's disease.[23] It most often begins in people over 65 years of age, although up to 10% of cases are early-onset affecting those in their 30's to mid 60's.[14][4] Women get sick more often than men.[24] It affects about 6% of people 65 years and older.[1] In 2015, all forms of dementia resulted in about 1.9 million deaths.[11] The disease is named after German psychiatrist and pathologist Alois Alzheimer, who first described it in 1906.[25] Alzheimer's financial burden on society is large, with a estimated global annual cost of US$1 trillion.[23]

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