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Obex

The meaning of «obex»

The obex (from the Latin for barrier) is the point in the human brain at which the fourth ventricle narrows to become the central canal of the spinal cord.

The decussation of sensory fibers happens at this point.

Lesions at the location can result in obstructive hydrocephalus. The most common lesion at this location is a subependymoma, a benign tumor.[1] Hemangioblastoma has been observed in this location.[2] Neurological surgical intervention in the treatment of syringomyelia or hydromyelia may involve plugging the obex to prevent the transmission of cerebrospinal fluid to the central canal of the spinal cord. Gardner suggested plugging of obex with muscle prevents transmission of CSF wave into central canal.[clarify][citation needed]

Immunohistochemistry (IHC) to test brain, lymph, and neuroendocrine tissues for the presence of the abnormal prion protein to diagnose wasting diseases like Chronic wasting disease in cervidae. Positive IHC findings in the obex is considered the gold standard.[3]

Fourth ventricle. Posterior view.Deep dissection.

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